What PolySafe actually does

Four things, done deliberately, rather than one big database done broadly.

Detect across more than just drug pairs

Most checkers only ask "does Drug A interact with Drug B?" PolySafe checks that too, but it also detects three other kinds of clinically relevant interaction:

Drug–Disease — e.g. propranolol prescribed to a patient with asthma or bradycardia.
Drug–Food/Drink — e.g. grapefruit juice raising exposure to nifedipine, midazolam or cyclosporine; cation-rich foods blocking fluoroquinolone absorption.
Drug–Laboratory Test — e.g. ceftriaxone causing a false-positive copper-reduction urine glucose test.

You add anything relevant to the patient's list — medicines, a condition, a food, a lab test — and PolySafe checks every possible pair between them.

Prioritize with a real severity scale

Every finding is classified on a single, consistent scale, so severity means the same thing everywhere in the app:

🚫 Contraindicated (C1)Should not be used together per authoritative labeling, absent a specific clinical override.

🔴 Major (C2)Clinically important — commonly needs avoidance, dose adjustment, or close monitoring.

🟠 Moderate (C3)Meaningful interaction where monitoring or adjustment may be appropriate.

🟡 Mild (C4)Limited clinical significance, or an analytical/lab artifact rather than a patient-harm risk.

Important distinction PolySafe keeps: severity is not the same as "avoid." Grapefruit juice + cyclosporine, for example, is Major (C2) with a clear "avoid" instruction — not automatically Contraindicated (C1). Reserving C1 for genuine, labeling-backed contraindications keeps the top tier meaningful.

Understand with the "Act Like a Pharmacist" breakdown

Selecting any finding opens a structured, consistent breakdown: contraindication status, risk, mechanism, clinical effect, monitoring, pharmacist considerations, and the evidence behind it. Two of the most time-critical sections — Monitoring and Pharmacist Considerations — also have their own quick-access buttons right on the result card, so you can jump straight to "what do I watch for" or "what do I actually do" without opening and scrolling the full panel.

Show its work — including what it doesn't know

If two items on the list have no curated record between them, PolySafe says so directly with a clear "no known interaction found" card, instead of silently doing nothing. That's a deliberate choice: no record means not yet reviewed, never confirmed safe.